Drug interactions
Ledipasvir-sofosbuvir + Sotorasib
Severity: Major
Ledipasvir-sofosbuvir and Sotorasib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-gp inducer, which can lower sofosbuvir and ledipasvir exposure. Reduced antiviral concentrations may compromise hepatitis C cure rates.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Sotorasib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ledipasvir-sofosbuvir belongs to Anti Virals; Sotorasib belongs to Oncology.
Why it happens
Sotorasib induces intestinal P-gp (and possibly CYP3A4), increasing efflux and reducing absorption of the antivirals.
What to do
Avoid combining if possible and consider deferring HCV treatment or using an alternative regimen. If unavoidable, monitor HCV RNA for virologic response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Sotorasib?
MediHelp rates the interaction as major. Ledipasvir-sofosbuvir and Sotorasib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotorasib is a P-gp inducer, which can lower sofosbuvir and ledipasvir exposure. Reduced antiviral concentrations may compromise hepatitis C cure rates.
How serious is the interaction between Ledipasvir-sofosbuvir and Sotorasib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if possible and consider deferring HCV treatment or using an alternative regimen. If unavoidable, monitor HCV RNA for virologic response.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
Full monographs, dosing and an interaction checker in the MediHelp app
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