Drug interactions
Ledipasvir / sofosbuvir + Topotecan
Severity: Moderate
Ledipasvir / sofosbuvir and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir inhibits P-gp and BCRP, which may increase topotecan exposure and raise the risk of myelosuppression.
What this interaction means in plain words
Ledipasvir / sofosbuvir and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ledipasvir inhibits intestinal P-gp and BCRP efflux of topotecan.
What to do
Avoid with oral topotecan; with IV topotecan, monitor blood counts for increased toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Frequently asked questions
Can I take Ledipasvir / sofosbuvir with Topotecan?
MediHelp rates the interaction as moderate. Ledipasvir / sofosbuvir and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir inhibits P-gp and BCRP, which may increase topotecan exposure and raise the risk of myelosuppression.
How serious is the interaction between Ledipasvir / sofosbuvir and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with oral topotecan; with IV topotecan, monitor blood counts for increased toxicity.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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