Drug interactions
Lefamulin + Lorlatinib
Severity: Moderate
Lefamulin and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may lower lefamulin concentrations by inducing CYP3A4 and P-gp, which could cause treatment failure of pneumonia, especially with the oral form.
What this interaction means in plain words
Lefamulin and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lefamulin belongs to Anti Bacterial; Lorlatinib belongs to Oncology.
Why it happens
CYP3A4 and P-gp induction by lorlatinib reduces lefamulin exposure.
What to do
Monitor for clinical response to the antibiotic or choose an alternative antibacterial agent for the short treatment course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Lorlatinib?
MediHelp rates the interaction as moderate. Lefamulin and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may lower lefamulin concentrations by inducing CYP3A4 and P-gp, which could cause treatment failure of pneumonia, especially with the oral form.
How serious is the interaction between Lefamulin and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clinical response to the antibiotic or choose an alternative antibacterial agent for the short treatment course.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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