Drug interactions
Lefamulin + Netupitant-palonosetron
Severity: Moderate
Lefamulin and Netupitant-palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin is a CYP3A4 substrate and may reach higher concentrations with a moderate CYP3A4 inhibitor like netupitant. Lefamulin can prolong the QT interval, so higher exposure alongside palonosetron may add to cardiac risk.
What this interaction means in plain words
Lefamulin and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lefamulin belongs to Anti Bacterial; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
CYP3A4 inhibition by netupitant increases lefamulin exposure, with possible additive QT effects.
What to do
Monitor for adverse effects including QT prolongation, especially in patients with other risk factors; consider an ECG in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Netupitant-palonosetron?
MediHelp rates the interaction as moderate. Lefamulin and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin is a CYP3A4 substrate and may reach higher concentrations with a moderate CYP3A4 inhibitor like netupitant. Lefamulin can prolong the QT interval, so higher exposure alongside palonosetron may add to cardiac risk.
How serious is the interaction between Lefamulin and Netupitant-palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects including QT prolongation, especially in patients with other risk factors; consider an ECG in high-risk patients.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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