Drug interactions
Lefamulin + Pazopanib
Severity: Major
Lefamulin and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin inhibits CYP3A4 and may raise pazopanib exposure, increasing the risk of hepatotoxicity. Both drugs prolong the QT interval, adding arrhythmia risk.
What this interaction means in plain words
Lefamulin and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lefamulin belongs to Anti Bacterial; Pazopanib belongs to Oncology.
Why it happens
Lefamulin inhibits CYP3A4 metabolism of pazopanib, with additive QT prolongation.
What to do
Use an alternative antibiotic where feasible. If used, monitor ECG, electrolytes and liver tests.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Pazopanib?
MediHelp rates the interaction as major. Lefamulin and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lefamulin inhibits CYP3A4 and may raise pazopanib exposure, increasing the risk of hepatotoxicity. Both drugs prolong the QT interval, adding arrhythmia risk.
How serious is the interaction between Lefamulin and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic where feasible. If used, monitor ECG, electrolytes and liver tests.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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