Drug interactions
Lefamulin + Salmeterol
Severity: Major
Lefamulin and Salmeterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin inhibits CYP3A4 and prolongs the QT interval, and salmeterol exposure may rise with oral lefamulin. Combined, they increase the risk of QT prolongation and arrhythmia.
What this interaction means in plain words
Lefamulin and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lefamulin belongs to Anti Bacterial; Salmeterol belongs to Respiratory.
Why it happens
CYP3A4 inhibition by lefamulin plus additive QT prolongation.
What to do
Avoid the combination if possible, or use a non-CYP3A4 alternative bronchodilator. If used, monitor ECG and electrolytes during the lefamulin course.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Salmeterol?
MediHelp rates the interaction as major. Lefamulin and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lefamulin inhibits CYP3A4 and prolongs the QT interval, and salmeterol exposure may rise with oral lefamulin. Combined, they increase the risk of QT prolongation and arrhythmia.
How serious is the interaction between Lefamulin and Salmeterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or use a non-CYP3A4 alternative bronchodilator. If used, monitor ECG and electrolytes during the lefamulin course.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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