Drug interactions
Lefamulin + Sorafenib
Severity: Moderate
Lefamulin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin inhibits CYP3A4, but sorafenib is cleared mainly via CYP3A4 and UGT1A9, so the effect on exposure is likely modest. Both drugs can prolong the QT interval, which is the main concern.
What this interaction means in plain words
Lefamulin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lefamulin belongs to Anti Bacterial; Sorafenib belongs to Oncology.
Why it happens
Additive QT prolongation, with a small contribution from CYP3A4 inhibition.
What to do
Obtain a baseline ECG, correct potassium and magnesium, and monitor QTc during co-treatment. Consider an alternative antibiotic in patients with existing QT risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Sorafenib?
MediHelp rates the interaction as moderate. Lefamulin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin inhibits CYP3A4, but sorafenib is cleared mainly via CYP3A4 and UGT1A9, so the effect on exposure is likely modest. Both drugs can prolong the QT interval, which is the main concern.
How serious is the interaction between Lefamulin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct potassium and magnesium, and monitor QTc during co-treatment. Consider an alternative antibiotic in patients with existing QT risk.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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