Drug interactions
Lefamulin + Telavancin
Severity: Major
Lefamulin and Telavancin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin prolongs the QT interval and is labeled with a warning about combining it with other QT-prolonging drugs. Telavancin may add to this effect, increasing the arrhythmia risk.
What this interaction means in plain words
Lefamulin and Telavancin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lefamulin belongs to Anti Bacterial; Telavancin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid using the two antibiotics together when another option exists. If both are required, check a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Telavancin?
MediHelp rates the interaction as major. Lefamulin and Telavancin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lefamulin prolongs the QT interval and is labeled with a warning about combining it with other QT-prolonging drugs. Telavancin may add to this effect, increasing the arrhythmia risk.
How serious is the interaction between Lefamulin and Telavancin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the two antibiotics together when another option exists. If both are required, check a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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