Drug interactions
Lefamulin + Triptorelin
Severity: Moderate
Lefamulin and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin can prolong the QT interval, and triptorelin may contribute through androgen deprivation. The combination may raise the risk of arrhythmia, particularly in patients with other risk factors.
What this interaction means in plain words
Lefamulin and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lefamulin belongs to Anti Bacterial; Triptorelin belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Consider a non-QT-prolonging antibiotic. If lefamulin is needed, check ECG and electrolytes and correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triptorelin
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Triptorelin?
MediHelp rates the interaction as moderate. Lefamulin and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin can prolong the QT interval, and triptorelin may contribute through androgen deprivation. The combination may raise the risk of arrhythmia, particularly in patients with other risk factors.
How serious is the interaction between Lefamulin and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-QT-prolonging antibiotic. If lefamulin is needed, check ECG and electrolytes and correct hypokalemia and hypomagnesemia.
What other medicines interact with Triptorelin?
MediHelp also lists interactions of Triptorelin with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Triptorelin page.
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