Drug interactions
Lemborexant + Pimozide
Severity: Moderate
Lemborexant and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide adds sedation to lemborexant, which can impair next-day alertness and psychomotor performance. Pimozide is a weak CYP3A4 inhibitor at most, so any effect on lemborexant levels is probably small.
What this interaction means in plain words
Lemborexant and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible minor CYP3A4-mediated increase in lemborexant exposure.
What to do
Use the lowest effective lemborexant dose and counsel patients on daytime drowsiness and driving. Monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Pimozide?
MediHelp rates the interaction as moderate. Lemborexant and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide adds sedation to lemborexant, which can impair next-day alertness and psychomotor performance. Pimozide is a weak CYP3A4 inhibitor at most, so any effect on lemborexant levels is probably small.
How serious is the interaction between Lemborexant and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose and counsel patients on daytime drowsiness and driving. Monitor for excessive sedation.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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