Drug interactions
Lemborexant + Remifentanil
Severity: Moderate
Lemborexant and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, so the combination increases sedation and impairs alertness and coordination. Next-day impairment is possible.
What this interaction means in plain words
Lemborexant and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive CNS depression from an opioid and an orexin receptor antagonist.
What to do
Use the lowest effective doses and monitor sedation and breathing. Counsel patients about impaired driving and psychomotor performance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Remifentanil?
MediHelp rates the interaction as moderate. Lemborexant and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, so the combination increases sedation and impairs alertness and coordination. Next-day impairment is possible.
How serious is the interaction between Lemborexant and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and breathing. Counsel patients about impaired driving and psychomotor performance.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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