Drug interactions
Lemborexant + Venlafaxine
Severity: Moderate
Lemborexant and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is an orexin receptor antagonist that causes somnolence, and venlafaxine may add to CNS effects such as dizziness or altered alertness. Next-morning impairment may be more likely.
What this interaction means in plain words
Lemborexant and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for daytime somnolence and impaired alertness. Consider using the lower 5 mg lemborexant dose and warn patients about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Venlafaxine?
MediHelp rates the interaction as moderate. Lemborexant and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant is an orexin receptor antagonist that causes somnolence, and venlafaxine may add to CNS effects such as dizziness or altered alertness. Next-morning impairment may be more likely.
How serious is the interaction between Lemborexant and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for daytime somnolence and impaired alertness. Consider using the lower 5 mg lemborexant dose and warn patients about driving.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
Full monographs, dosing and an interaction checker in the MediHelp app
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