Drug interactions
Lenacapavir + Tofacitinib
Severity: Moderate
Lenacapavir and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor, and its long-acting subcutaneous form can have effects lasting for months after dosing. Tofacitinib levels may rise modestly, increasing the risk of dose-related adverse effects.
What this interaction means in plain words
Lenacapavir and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Tofacitinib belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4 reduces tofacitinib metabolism.
What to do
No routine dose change is needed; monitor for infection and cytopenias, including for months after the last lenacapavir injection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Tofacitinib?
MediHelp rates the interaction as moderate. Lenacapavir and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A4 inhibitor, and its long-acting subcutaneous form can have effects lasting for months after dosing. Tofacitinib levels may rise modestly, increasing the risk of dose-related adverse effects.
How serious is the interaction between Lenacapavir and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for infection and cytopenias, including for months after the last lenacapavir injection.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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