Drug interactions
Lenacapavir + Ulipristal
Severity: Moderate
Lenacapavir and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor with a long half-life, so ulipristal exposure may rise for months after the last injection. Consequences of increased exposure are not well characterized.
What this interaction means in plain words
Lenacapavir and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lenacapavir inhibits CYP3A4, reducing ulipristal metabolism.
What to do
Prefer a copper IUD or alternative emergency contraception. If ulipristal is used, counsel about possible increased adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Ulipristal?
MediHelp rates the interaction as moderate. Lenacapavir and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A4 inhibitor with a long half-life, so ulipristal exposure may rise for months after the last injection. Consequences of increased exposure are not well characterized.
How serious is the interaction between Lenacapavir and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a copper IUD or alternative emergency contraception. If ulipristal is used, counsel about possible increased adverse effects.
What other medicines interact with Lenacapavir?
MediHelp also lists interactions of Lenacapavir with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Lenacapavir page.
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