Drug interactions
Lenacapavir + Venlafaxine
Severity: Minor
Lenacapavir and Venlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may raise exposure to CYP3A substrates, including venlafaxine, which is partly metabolised by this enzyme. The effect on venlafaxine is probably small because CYP2D6 is its main pathway.
What this interaction means in plain words
Lenacapavir and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lenacapavir belongs to Anti Virals; Venlafaxine belongs to Central Nervous System.
Why it happens
Moderate CYP3A inhibition by lenacapavir reduces venlafaxine clearance via a minor pathway.
What to do
No routine dose change is needed. Monitor blood pressure and tolerability of venlafaxine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Venlafaxine?
MediHelp rates the interaction as minor. Lenacapavir and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A inhibitor and may raise exposure to CYP3A substrates, including venlafaxine, which is partly metabolised by this enzyme. The effect on venlafaxine is probably small because CYP2D6 is its main pathway.
How serious is the interaction between Lenacapavir and Venlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor blood pressure and tolerability of venlafaxine.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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