Drug interactions
Leniolisib + Pitavastatin
Severity: Moderate
Leniolisib and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP, OATP1B1 and OATP1B3, the transporters handling pitavastatin. Exposure to the statin may rise, increasing the risk of myopathy.
What this interaction means in plain words
Leniolisib and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Pitavastatin belongs to Cardiovascular.
Why it happens
Leniolisib inhibits hepatic uptake (OATP1B1/1B3) and efflux (BCRP) of pitavastatin.
What to do
Monitor for muscle symptoms and consider reducing pitavastatin dose during coadministration. Choose a less transporter-dependent statin if problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Pitavastatin?
MediHelp rates the interaction as moderate. Leniolisib and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits BCRP, OATP1B1 and OATP1B3, the transporters handling pitavastatin. Exposure to the statin may rise, increasing the risk of myopathy.
How serious is the interaction between Leniolisib and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and consider reducing pitavastatin dose during coadministration. Choose a less transporter-dependent statin if problems arise.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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