Drug interactions
Leniolisib + Telmisartan-amlodipine
Severity: Moderate
Leniolisib and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1 and OATP1B3 and may raise exposure to substrates. Telmisartan is a substrate of hepatic uptake transporters, so higher levels and enhanced blood pressure lowering or adverse effects are possible.
What this interaction means in plain words
Leniolisib and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Leniolisib inhibits OATP1B1/1B3 hepatic uptake, potentially raising telmisartan plasma concentrations.
What to do
Monitor blood pressure, renal function and potassium when starting leniolisib. Reduce the telmisartan dose if hypotension or other adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Leniolisib and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits OATP1B1 and OATP1B3 and may raise exposure to substrates. Telmisartan is a substrate of hepatic uptake transporters, so higher levels and enhanced blood pressure lowering or adverse effects are possible.
How serious is the interaction between Leniolisib and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium when starting leniolisib. Reduce the telmisartan dose if hypotension or other adverse effects occur.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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