Drug interactions
Leniolisib + Telmisartan
Severity: Moderate
Leniolisib and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1 and OATP1B3 and may increase exposure to substrates of these transporters. Telmisartan's disposition is only partly OATP-dependent, so any rise in exposure is probably modest, with possible increased hypotension or renal effects.
What this interaction means in plain words
Leniolisib and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Telmisartan belongs to Cardiovascular.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake by leniolisib may raise telmisartan plasma levels.
What to do
Monitor blood pressure, renal function and potassium when starting leniolisib. Reduce the telmisartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Telmisartan?
MediHelp rates the interaction as moderate. Leniolisib and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits OATP1B1 and OATP1B3 and may increase exposure to substrates of these transporters. Telmisartan's disposition is only partly OATP-dependent, so any rise in exposure is probably modest, with possible increased hypotension or renal effects.
How serious is the interaction between Leniolisib and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium when starting leniolisib. Reduce the telmisartan dose if hypotension occurs.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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