Drug interactions
Leniolisib + Tenofovir disoproxil
Severity: Minor
Leniolisib and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP and may increase exposure to BCRP substrates. Tenofovir is mainly handled by P-gp and renal transporters, so a clinically relevant increase is uncertain.
What this interaction means in plain words
Leniolisib and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible BCRP inhibition raising tenofovir absorption.
What to do
No empirical dose change is needed. Monitor renal function and tenofovir adverse effects during long-term co-administration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Leniolisib and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib inhibits BCRP and may increase exposure to BCRP substrates. Tenofovir is mainly handled by P-gp and renal transporters, so a clinically relevant increase is uncertain.
How serious is the interaction between Leniolisib and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor renal function and tenofovir adverse effects during long-term co-administration.
What other medicines interact with Leniolisib?
MediHelp also lists interactions of Leniolisib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Leniolisib page.
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