Drug interactions
Leniolisib + Theophylline
Severity: Major
Leniolisib and Theophylline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib has been shown to raise exposure to CYP1A2 substrates, and theophylline is a sensitive CYP1A2 substrate with a narrow therapeutic index. Higher levels may cause nausea, tachycardia, arrhythmias and seizures.
What this interaction means in plain words
Leniolisib and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Leniolisib belongs to Miscellaneous; Theophylline belongs to Respiratory.
Why it happens
Leniolisib inhibits CYP1A2, reducing hepatic clearance of theophylline.
What to do
Avoid combining if possible; otherwise reduce the theophylline dose and monitor serum concentrations closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Theophylline?
MediHelp rates the interaction as major. Leniolisib and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Leniolisib has been shown to raise exposure to CYP1A2 substrates, and theophylline is a sensitive CYP1A2 substrate with a narrow therapeutic index. Higher levels may cause nausea, tachycardia, arrhythmias and seizures.
How serious is the interaction between Leniolisib and Theophylline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if possible; otherwise reduce the theophylline dose and monitor serum concentrations closely.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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