Drug interactions
Lesinurad + Norethindrone
Severity: Moderate
Lesinurad and Norethindrone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lesinurad is a weak inducer of CYP3A and may lower circulating progestin concentrations. This could reduce the contraceptive reliability of norethindrone-containing products and raise the chance of unintended pregnancy.
What this interaction means in plain words
Lesinurad and Norethindrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lesinurad induces CYP3A4, increasing the metabolic clearance of norethindrone.
What to do
Advise patients to use an additional non-hormonal contraceptive method while taking lesinurad. Do not rely on hormonal contraception alone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Frequently asked questions
Can I take Lesinurad with Norethindrone?
MediHelp rates the interaction as moderate. Lesinurad and Norethindrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lesinurad is a weak inducer of CYP3A and may lower circulating progestin concentrations. This could reduce the contraceptive reliability of norethindrone-containing products and raise the chance of unintended pregnancy.
How serious is the interaction between Lesinurad and Norethindrone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to use an additional non-hormonal contraceptive method while taking lesinurad. Do not rely on hormonal contraception alone.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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