Drug interactions
Lesinurad + Phenytoin
Severity: Minor
Lesinurad and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces hepatic enzymes and may decrease lesinurad exposure, potentially reducing its urate-lowering effect.
What this interaction means in plain words
Lesinurad and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lesinurad belongs to Genitourinary; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP enzymes including CYP2C9, increasing lesinurad clearance.
What to do
Monitor serum uric acid and gout flares when phenytoin is started or stopped. Consider alternative therapy if control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Lesinurad with Phenytoin?
MediHelp rates the interaction as minor. Lesinurad and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin induces hepatic enzymes and may decrease lesinurad exposure, potentially reducing its urate-lowering effect.
How serious is the interaction between Lesinurad and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout flares when phenytoin is started or stopped. Consider alternative therapy if control is inadequate.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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