Drug interactions
Letermovir + Pimozide
Severity: Contraindicated
Letermovir and Pimozide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 and can increase exposure to pimozide. Higher pimozide levels increase the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Letermovir and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Letermovir belongs to Anti Virals; Pimozide belongs to Central Nervous System.
Why it happens
Letermovir inhibits CYP3A4 metabolism of pimozide.
What to do
Do not coadminister, as labeling contraindicates it. Consider switching pimozide to another agent during CMV prophylaxis.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
- Cyclosporin + Letermovir Major
Frequently asked questions
Can I take Letermovir with Pimozide?
MediHelp rates the interaction as contraindicated. Letermovir and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Letermovir inhibits CYP3A4 and can increase exposure to pimozide. Higher pimozide levels increase the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Letermovir and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister, as labeling contraindicates it. Consider switching pimozide to another agent during CMV prophylaxis.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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