Drug interactions
Colchicine + Letermovir
Severity: Major
Colchicine and Letermovir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 moderately and may raise colchicine concentrations. This increases the risk of colchicine toxicity such as myopathy, diarrhea and cytopenias.
What this interaction means in plain words
Colchicine and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP3A4 (and transporters), reducing colchicine elimination.
What to do
Reduce the colchicine dose and monitor for signs of toxicity. Avoid the combination in patients with renal or hepatic impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Cyclosporin + Letermovir Major
Frequently asked questions
Can I take Colchicine with Letermovir?
MediHelp rates the interaction as major. Colchicine and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir inhibits CYP3A4 moderately and may raise colchicine concentrations. This increases the risk of colchicine toxicity such as myopathy, diarrhea and cytopenias.
How serious is the interaction between Colchicine and Letermovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the colchicine dose and monitor for signs of toxicity. Avoid the combination in patients with renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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