Drug interactions
Leuprorelin + Methadone
Severity: Major
Leuprorelin and Methadone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy can prolong the QT interval, and methadone also prolongs QT. Together they increase the risk of torsades de pointes.
What this interaction means in plain words
Leuprorelin and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Leuprorelin belongs to Musculoskeletal; Methadone belongs to Musculoskeletal.
Why it happens
Additive QT prolongation through pharmacodynamic effects.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes, correcting potassium and magnesium; consider alternatives if QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Leuprorelin
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Leuprorelin with Methadone?
MediHelp rates the interaction as major. Leuprorelin and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Androgen deprivation therapy can prolong the QT interval, and methadone also prolongs QT. Together they increase the risk of torsades de pointes.
How serious is the interaction between Leuprorelin and Methadone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes, correcting potassium and magnesium; consider alternatives if QTc becomes prolonged.
What other medicines interact with Leuprorelin?
MediHelp also lists interactions of Leuprorelin with, for example, Moxifloxacin. The full list is on the Leuprorelin page.
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