Drug interactions
Leuprorelin + Moxifloxacin
Severity: Major
Leuprorelin and Moxifloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy can prolong the QT interval, and moxifloxacin also prolongs QT. Together they increase the risk of torsades de pointes.
What this interaction means in plain words
Leuprorelin and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Leuprorelin belongs to Musculoskeletal; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation through pharmacodynamic effects.
What to do
Prefer a non-QT-prolonging antibiotic where possible; otherwise monitor ECG and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Leuprorelin
- Leuprorelin + Methadone Major
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Leuprorelin with Moxifloxacin?
MediHelp rates the interaction as major. Leuprorelin and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Androgen deprivation therapy can prolong the QT interval, and moxifloxacin also prolongs QT. Together they increase the risk of torsades de pointes.
How serious is the interaction between Leuprorelin and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-QT-prolonging antibiotic where possible; otherwise monitor ECG and correct electrolytes.
What other medicines interact with Leuprorelin?
MediHelp also lists interactions of Leuprorelin with, for example, Methadone. The full list is on the Leuprorelin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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