Drug interactions
Levetiracetam + Meclizine
Severity: Moderate
Levetiracetam and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is a sedating antihistamine, and levetiracetam also commonly causes somnolence and dizziness. Together they may increase drowsiness and unsteadiness.
What this interaction means in plain words
Levetiracetam and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Meclizine belongs to Respiratory.
Why it happens
Additive CNS depressant effects.
What to do
Counsel patients about drowsiness and fall risk, and avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Meclizine
Frequently asked questions
Can I take Levetiracetam with Meclizine?
MediHelp rates the interaction as moderate. Levetiracetam and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is a sedating antihistamine, and levetiracetam also commonly causes somnolence and dizziness. Together they may increase drowsiness and unsteadiness.
How serious is the interaction between Levetiracetam and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and fall risk, and avoid driving until the response is known.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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