Drug interactions
Levetiracetam + Meprobamate
Severity: Moderate
Levetiracetam and Meprobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can increase drowsiness, dizziness and impaired psychomotor performance. Falls and accidents are the main concern, especially in older patients.
What this interaction means in plain words
Levetiracetam and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Monitor for excess sedation and counsel patients about driving and operating machinery. Consider lowering the meprobamate dose in elderly or frail patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Meprobamate?
MediHelp rates the interaction as moderate. Levetiracetam and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can increase drowsiness, dizziness and impaired psychomotor performance. Falls and accidents are the main concern, especially in older patients.
How serious is the interaction between Levetiracetam and Meprobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and counsel patients about driving and operating machinery. Consider lowering the meprobamate dose in elderly or frail patients.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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