Drug interactions
Levetiracetam + Metoclopramide intranasal
Severity: Moderate
Levetiracetam and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause drowsiness and extrapyramidal effects and may lower seizure threshold in susceptible patients. Levetiracetam adds somnolence, and metoclopramide may reduce seizure control in people with epilepsy.
What this interaction means in plain words
Levetiracetam and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS effects; metoclopramide's dopamine antagonism may also reduce seizure threshold, though the mechanism is not firmly established.
What to do
Monitor seizure frequency and sedation when metoclopramide is started in a patient on levetiracetam. Choose an alternative antiemetic with less CNS activity if seizure control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Levetiracetam and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause drowsiness and extrapyramidal effects and may lower seizure threshold in susceptible patients. Levetiracetam adds somnolence, and metoclopramide may reduce seizure control in people with epilepsy.
How serious is the interaction between Levetiracetam and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and sedation when metoclopramide is started in a patient on levetiracetam. Choose an alternative antiemetic with less CNS activity if seizure control worsens.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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