Drug interactions
Levetiracetam + Midazolam intranasal
Severity: Moderate
Levetiracetam and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a potent benzodiazepine that causes sedation and respiratory depression. Levetiracetam adds CNS depressant effects, which may deepen or prolong sedation. Respiratory compromise is the main concern.
What this interaction means in plain words
Levetiracetam and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system and respiratory depression.
What to do
Monitor respiration, oxygen saturation and level of consciousness after midazolam dosing. Ensure that resuscitation support is available, particularly if other sedatives are also given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Midazolam intranasal?
MediHelp rates the interaction as moderate. Levetiracetam and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam is a potent benzodiazepine that causes sedation and respiratory depression. Levetiracetam adds CNS depressant effects, which may deepen or prolong sedation. Respiratory compromise is the main concern.
How serious is the interaction between Levetiracetam and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiration, oxygen saturation and level of consciousness after midazolam dosing. Ensure that resuscitation support is available, particularly if other sedatives are also given.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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