Drug interactions
Levetiracetam + Molindone
Severity: Moderate
Levetiracetam and Molindone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Molindone is a sedating antipsychotic and levetiracetam also causes somnolence and fatigue. Together they may produce greater drowsiness and psychomotor slowing, and levetiracetam may also add behavioral side effects.
What this interaction means in plain words
Levetiracetam and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Monitor for sedation and mood or behavioral changes, especially after dose changes. Adjust the dose of the more sedating agent if daytime drowsiness interferes with function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Molindone?
MediHelp rates the interaction as moderate. Levetiracetam and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Molindone is a sedating antipsychotic and levetiracetam also causes somnolence and fatigue. Together they may produce greater drowsiness and psychomotor slowing, and levetiracetam may also add behavioral side effects.
How serious is the interaction between Levetiracetam and Molindone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and mood or behavioral changes, especially after dose changes. Adjust the dose of the more sedating agent if daytime drowsiness interferes with function.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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