Drug interactions
Levetiracetam + Nitrous oxide
Severity: Moderate
Levetiracetam and Nitrous oxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrous oxide has sedative and anesthetic effects that may be added to the somnolence caused by levetiracetam. This may deepen sedation or prolong recovery in the perioperative or dental setting.
What this interaction means in plain words
Levetiracetam and Nitrous oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Continue levetiracetam without interruption around procedures and monitor sedation depth and recovery. Titrate nitrous oxide to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Nitrous oxide?
MediHelp rates the interaction as moderate. Levetiracetam and Nitrous oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrous oxide has sedative and anesthetic effects that may be added to the somnolence caused by levetiracetam. This may deepen sedation or prolong recovery in the perioperative or dental setting.
How serious is the interaction between Levetiracetam and Nitrous oxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue levetiracetam without interruption around procedures and monitor sedation depth and recovery. Titrate nitrous oxide to effect.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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