Drug interactions
Levetiracetam + Olanzapine / samidorphan
Severity: Moderate
Levetiracetam and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine is markedly sedating and levetiracetam can cause somnolence and dizziness. The combination may produce additive drowsiness and impaired alertness.
What this interaction means in plain words
Levetiracetam and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Monitor for daytime sedation and orthostatic dizziness, particularly during initiation. Counsel patients about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Levetiracetam and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine is markedly sedating and levetiracetam can cause somnolence and dizziness. The combination may produce additive drowsiness and impaired alertness.
How serious is the interaction between Levetiracetam and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for daytime sedation and orthostatic dizziness, particularly during initiation. Counsel patients about driving and operating machinery.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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