Drug interactions
Levetiracetam + Orphenadrine
Severity: Moderate
Levetiracetam and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is an anticholinergic muscle relaxant that causes drowsiness, dizziness and confusion. Together with levetiracetam, sedation and cognitive impairment may be increased, particularly in older adults.
What this interaction means in plain words
Levetiracetam and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Monitor for sedation, confusion and falls, and use the lowest orphenadrine dose for the shortest time. Avoid this combination in frail elderly patients where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Orphenadrine?
MediHelp rates the interaction as moderate. Levetiracetam and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is an anticholinergic muscle relaxant that causes drowsiness, dizziness and confusion. Together with levetiracetam, sedation and cognitive impairment may be increased, particularly in older adults.
How serious is the interaction between Levetiracetam and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and falls, and use the lowest orphenadrine dose for the shortest time. Avoid this combination in frail elderly patients where possible.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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