Drug interactions
Levetiracetam + Protriptyline
Severity: Moderate
Levetiracetam and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic antidepressant with less sedation than most of its class but still may cause drowsiness and dizziness. Combined with levetiracetam, mild additive sedation can occur, and both drugs can affect mood or seizure threshold.
What this interaction means in plain words
Levetiracetam and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Monitor for sedation and for changes in seizure control or mood. Reduce doses if daytime impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Protriptyline?
MediHelp rates the interaction as moderate. Levetiracetam and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is a tricyclic antidepressant with less sedation than most of its class but still may cause drowsiness and dizziness. Combined with levetiracetam, mild additive sedation can occur, and both drugs can affect mood or seizure threshold.
How serious is the interaction between Levetiracetam and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for changes in seizure control or mood. Reduce doses if daytime impairment occurs.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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