Drug interactions
Levetiracetam + Remimazolam
Severity: Moderate
Levetiracetam and Remimazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is a short-acting benzodiazepine sedative whose effects are enhanced by other CNS depressants. Levetiracetam may add to sedation and could deepen it beyond the intended level.
What this interaction means in plain words
Levetiracetam and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Titrate remimazolam carefully to the desired sedation level and monitor oxygenation and respiration. Continue levetiracetam to avoid seizure risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levetiracetam and Remimazolam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Levetiracetam
Other interactions of Remimazolam
Frequently asked questions
Can I take Levetiracetam with Remimazolam?
MediHelp rates the interaction as moderate. Levetiracetam and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remimazolam is a short-acting benzodiazepine sedative whose effects are enhanced by other CNS depressants. Levetiracetam may add to sedation and could deepen it beyond the intended level.
How serious is the interaction between Levetiracetam and Remimazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully to the desired sedation level and monitor oxygenation and respiration. Continue levetiracetam to avoid seizure risk.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
