Drug interactions
Levetiracetam + Sage
Severity: Minor
Levetiracetam and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some sage species contain thujone, a convulsant when taken in large amounts. High intake of sage oil or concentrated supplements could theoretically lower the seizure threshold and reduce levetiracetam's protection. Culinary use is unlikely to matter.
What this interaction means in plain words
Levetiracetam and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thujone-containing sage may have pro-convulsant effects that oppose the antiseizure action.
What to do
Advise patients with epilepsy to avoid sage essential oils and concentrated supplements.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Sage?
MediHelp rates the interaction as minor. Levetiracetam and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some sage species contain thujone, a convulsant when taken in large amounts. High intake of sage oil or concentrated supplements could theoretically lower the seizure threshold and reduce levetiracetam's protection. Culinary use is unlikely to matter.
How serious is the interaction between Levetiracetam and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients with epilepsy to avoid sage essential oils and concentrated supplements.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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