Drug interactions
Levetiracetam + Tiagabine
Severity: Moderate
Levetiracetam and Tiagabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both antiseizure drugs can cause somnolence, dizziness and fatigue. Combined use may intensify these effects, which is relevant for falls and daily functioning.
What this interaction means in plain words
Levetiracetam and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects; no significant pharmacokinetic interaction is established.
What to do
Monitor for sedation and dizziness during titration and advise caution with driving. Adjust doses gradually according to seizure control and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Tiagabine?
MediHelp rates the interaction as moderate. Levetiracetam and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both antiseizure drugs can cause somnolence, dizziness and fatigue. Combined use may intensify these effects, which is relevant for falls and daily functioning.
How serious is the interaction between Levetiracetam and Tiagabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness during titration and advise caution with driving. Adjust doses gradually according to seizure control and tolerability.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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