Drug interactions
Levetiracetam + Triazolam
Severity: Moderate
Levetiracetam and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is a potent short-acting benzodiazepine hypnotic that impairs alertness and psychomotor function. Levetiracetam can cause somnolence and dizziness, so the combination may increase next-day sedation and the risk of falls or accidents.
What this interaction means in plain words
Levetiracetam and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; triazolam enhances GABA-A receptor activity.
What to do
Use the lowest effective triazolam dose for the shortest time and monitor for daytime drowsiness. Take particular care in older patients and warn against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Triazolam?
MediHelp rates the interaction as moderate. Levetiracetam and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triazolam is a potent short-acting benzodiazepine hypnotic that impairs alertness and psychomotor function. Levetiracetam can cause somnolence and dizziness, so the combination may increase next-day sedation and the risk of falls or accidents.
How serious is the interaction between Levetiracetam and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective triazolam dose for the shortest time and monitor for daytime drowsiness. Take particular care in older patients and warn against driving.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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