Drug interactions
Levetiracetam + Trifluoperazine
Severity: Moderate
Levetiracetam and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and psychomotor slowing. Together they may produce greater drowsiness and dizziness, raising the risk of falls and accidents.
What this interaction means in plain words
Levetiracetam and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of levetiracetam and the antihistaminic and antiadrenergic effects of the phenothiazine.
What to do
Monitor for oversedation, especially in older adults, and warn about driving. Lower the dose of one agent if sedation interferes with function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Trifluoperazine?
MediHelp rates the interaction as moderate. Levetiracetam and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and psychomotor slowing. Together they may produce greater drowsiness and dizziness, raising the risk of falls and accidents.
How serious is the interaction between Levetiracetam and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, especially in older adults, and warn about driving. Lower the dose of one agent if sedation interferes with function.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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