Drug interactions
Levetiracetam + Zolpidem
Severity: Moderate
Levetiracetam and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levetiracetam frequently causes somnolence, dizziness and fatigue, and zolpidem may add to these effects. Alertness and coordination can be impaired.
What this interaction means in plain words
Levetiracetam and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Additive CNS depression from SV2A modulation and GABA-A potentiation.
What to do
Use the lowest effective zolpidem dose and monitor for oversedation and dizziness. Counsel on driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Zolpidem?
MediHelp rates the interaction as moderate. Levetiracetam and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levetiracetam frequently causes somnolence, dizziness and fatigue, and zolpidem may add to these effects. Alertness and coordination can be impaired.
How serious is the interaction between Levetiracetam and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective zolpidem dose and monitor for oversedation and dizziness. Counsel on driving and fall risk.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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