Drug interactions
Levocetirizine + Midazolam intranasal
Severity: Moderate
Levocetirizine and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a benzodiazepine that depresses the CNS and breathing, and other sedatives can intensify and prolong this effect. Levocetirizine has relatively mild sedative activity, but the combination can still increase the risk of hypoventilation.
What this interaction means in plain words
Levocetirizine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression.
What to do
Monitor respiratory rate, oxygen saturation and level of consciousness after midazolam dosing. Ensure supervision and avoid other sedatives where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levocetirizine
Frequently asked questions
Can I take Levocetirizine with Midazolam intranasal?
MediHelp rates the interaction as moderate. Levocetirizine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam is a benzodiazepine that depresses the CNS and breathing, and other sedatives can intensify and prolong this effect. Levocetirizine has relatively mild sedative activity, but the combination can still increase the risk of hypoventilation.
How serious is the interaction between Levocetirizine and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate, oxygen saturation and level of consciousness after midazolam dosing. Ensure supervision and avoid other sedatives where possible.
What other medicines interact with Levocetirizine?
MediHelp also lists interactions of Levocetirizine with, for example, Acrivastine, Asenapine transdermal, Avapritinib. The full list is on the Levocetirizine page.
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