Drug interactions
Levodopa + Perindopril
Severity: Moderate
Levodopa and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension and may add to the blood pressure lowering of perindopril. Patients may experience dizziness or falls, especially when starting or increasing either drug.
What this interaction means in plain words
Levodopa and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levodopa belongs to Central Nervous System; Perindopril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects: levodopa-derived dopamine causes vasodilation and reduced sympathetic tone, while ACE inhibitors reduce angiotensin II.
What to do
Monitor blood pressure and orthostatic symptoms when either drug is started or adjusted. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Perindopril?
MediHelp rates the interaction as moderate. Levodopa and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension and may add to the blood pressure lowering of perindopril. Patients may experience dizziness or falls, especially when starting or increasing either drug.
How serious is the interaction between Levodopa and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when either drug is started or adjusted. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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