Drug interactions
Levodopa inhaled + Tranylcypromine
Severity: Contraindicated
Levodopa inhaled and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled levodopa is absorbed systemically and converted to dopamine, so nonselective MAO inhibition can cause hypertensive crisis. Labeling contraindicates its use with nonselective MAOIs.
What this interaction means in plain words
Levodopa inhaled and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Increased catecholamine formation with blocked MAO degradation causes exaggerated pressor responses.
What to do
Do not use together. Stop the nonselective MAOI at least 14 days before starting inhaled levodopa.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Levodopa inhaled with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Levodopa inhaled and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Inhaled levodopa is absorbed systemically and converted to dopamine, so nonselective MAO inhibition can cause hypertensive crisis. Labeling contraindicates its use with nonselective MAOIs.
How serious is the interaction between Levodopa inhaled and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Stop the nonselective MAOI at least 14 days before starting inhaled levodopa.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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