Drug interactions
Levofloxacin + Magnesium supplement
Severity: Moderate
Levofloxacin and Magnesium supplement: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium binds levofloxacin in the gut and reduces its absorption, which can lower antibiotic concentrations enough to risk treatment failure.
What this interaction means in plain words
Levofloxacin and Magnesium supplement can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of levofloxacin by divalent magnesium cations forms poorly absorbed complexes in the gastrointestinal tract.
What to do
Give levofloxacin at least 2 hours before or 2 hours after the magnesium supplement. Where possible, avoid magnesium-containing products during the antibiotic course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Magnesium supplement?
MediHelp rates the interaction as moderate. Levofloxacin and Magnesium supplement can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium binds levofloxacin in the gut and reduces its absorption, which can lower antibiotic concentrations enough to risk treatment failure.
How serious is the interaction between Levofloxacin and Magnesium supplement?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give levofloxacin at least 2 hours before or 2 hours after the magnesium supplement. Where possible, avoid magnesium-containing products during the antibiotic course.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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