Drug interactions
Levofloxacin + Microbiota
Severity: Major
Levofloxacin and Microbiota: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral microbiota products contain live bacterial spores intended to restore gut flora. Active antibiotic in the gut can kill or inhibit the organisms and reduce the effectiveness of the product.
What this interaction means in plain words
Levofloxacin and Microbiota can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Antibacterial activity of levofloxacin against the live bacteria in the microbiota product reduces engraftment.
What to do
Complete the antibiotic course and allow the interval stated in the product labeling (typically a few days) before giving the microbiota product.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Microbiota?
MediHelp rates the interaction as major. Levofloxacin and Microbiota can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral microbiota products contain live bacterial spores intended to restore gut flora. Active antibiotic in the gut can kill or inhibit the organisms and reduce the effectiveness of the product.
How serious is the interaction between Levofloxacin and Microbiota?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the antibiotic course and allow the interval stated in the product labeling (typically a few days) before giving the microbiota product.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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