Drug interactions
Levofloxacin + Mometasone inhaled
Severity: Minor
Levofloxacin and Mometasone inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids increase the risk of fluoroquinolone-associated tendinopathy and tendon rupture. Inhaled mometasone has low systemic exposure, so the added risk is small, though it may be greater with high doses or in older patients.
What this interaction means in plain words
Levofloxacin and Mometasone inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive tendon toxicity from corticosteroid effects on collagen and fluoroquinolone tendon injury.
What to do
Advise the patient to stop levofloxacin and seek review if tendon pain or swelling develops. Be extra vigilant in older patients or those on high-dose or additional systemic steroids.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Mometasone inhaled?
MediHelp rates the interaction as minor. Levofloxacin and Mometasone inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids increase the risk of fluoroquinolone-associated tendinopathy and tendon rupture. Inhaled mometasone has low systemic exposure, so the added risk is small, though it may be greater with high doses or in older patients.
How serious is the interaction between Levofloxacin and Mometasone inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to stop levofloxacin and seek review if tendon pain or swelling develops. Be extra vigilant in older patients or those on high-dose or additional systemic steroids.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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