Drug interactions
Levofloxacin + Olanzapine / samidorphan
Severity: Minor
Levofloxacin and Olanzapine / samidorphan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin is at most a weak CYP1A2 inhibitor and is unlikely to raise olanzapine exposure meaningfully. Any effect would be small, though both drugs can affect QT interval in susceptible patients.
What this interaction means in plain words
Levofloxacin and Olanzapine / samidorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP1A2-mediated olanzapine metabolism is possible but is not well established for levofloxacin.
What to do
No dose change is normally needed. Monitor for sedation, orthostatic hypotension and QT-related symptoms if other risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Olanzapine / samidorphan?
MediHelp rates the interaction as minor. Levofloxacin and Olanzapine / samidorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levofloxacin is at most a weak CYP1A2 inhibitor and is unlikely to raise olanzapine exposure meaningfully. Any effect would be small, though both drugs can affect QT interval in susceptible patients.
How serious is the interaction between Levofloxacin and Olanzapine / samidorphan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed. Monitor for sedation, orthostatic hypotension and QT-related symptoms if other risk factors are present.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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