Drug interactions
Levofloxacin + Olanzapine
Severity: Moderate
Levofloxacin and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, though olanzapine's effect is generally modest. Together they may increase the risk of torsades de pointes, especially with other risk factors.
What this interaction means in plain words
Levofloxacin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Olanzapine belongs to Central Nervous System.
Why it happens
Additive delay in ventricular repolarization via hERG potassium channel blockade.
What to do
Check electrolytes and consider a baseline ECG in at-risk patients. Monitor the QTc and avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Levofloxacin with Olanzapine?
MediHelp rates the interaction as moderate. Levofloxacin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, though olanzapine's effect is generally modest. Together they may increase the risk of torsades de pointes, especially with other risk factors.
How serious is the interaction between Levofloxacin and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check electrolytes and consider a baseline ECG in at-risk patients. Monitor the QTc and avoid adding further QT-prolonging drugs.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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