Drug interactions
Levofloxacin + Olodaterol inhaled
Severity: Moderate
Levofloxacin and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin prolongs the QT interval, and long-acting beta2 agonists such as olodaterol can cause hypokalemia and cardiovascular stimulation. Combined use may modestly increase the risk of ventricular arrhythmias, mainly in susceptible patients.
What this interaction means in plain words
Levofloxacin and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta2-agonist-induced hypokalemia and sympathetic stimulation increasing arrhythmia risk.
What to do
Monitor for palpitations or syncope and check potassium in patients with cardiac disease or other QT risk factors. Obtain an ECG if QT prolongation is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Levofloxacin and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levofloxacin prolongs the QT interval, and long-acting beta2 agonists such as olodaterol can cause hypokalemia and cardiovascular stimulation. Combined use may modestly increase the risk of ventricular arrhythmias, mainly in susceptible patients.
How serious is the interaction between Levofloxacin and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations or syncope and check potassium in patients with cardiac disease or other QT risk factors. Obtain an ECG if QT prolongation is suspected.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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